HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-Methyl-3-hydroxy-4-chloromethyl-5-vinylpyridine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-Methyl-3-hydroxy-4-hydroxymethyl-5-vinylpyridine hydrochloride | HCID 20263933 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Methyl-3-hydroxy-4-chloromethyl-5-vinylpyridine hydrochloride | HCID 20263972 | — |
Reaction Steps
A mixture of 1.65 g. of 2-methyl-3-hydroxy-4-hydroxymethyl-5-vinylpyridine hydrochloride, 1 ml. of thionyl chloride and 20 ml. of tetrahydrofuran is refluxed 6 hours. After cooling, the precipitate is collected on a filter, washed with ether and dried to give 2-methyl-3-hydroxy-4-chloromethyl-5-vinyl pyridine hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04061759 |
| Source dataset | uspto-grants-1977_12 |
| ORD ID | ord-1c54566ef0c443328b6dffc04b37edde |
| Source note | uspto-grants-1977_12 |