反应详情

2-Methyl-5-hydroxymethylpyridine (0.1 mole) is stirred in pyridine (50 ml.) with acetic anhydride (0.15 ) mole) at room temperature overnight. The mixture is concentrated to dryness, and the residue is dissolved in 70 ml. of water and extracted with 3 × 25 ml. of chloroform. After drying over magnesium sulfate, the chloroform is concentrated to dryness to give 2-methyl-5-acetoxymethylpyridine.

1. concentrationThe mixture is concentrated to dryness
2. dissolutionthe residue is dissolved in 70 ml
3. extractionof water and extracted with 3 × 25 ml
4. dry with materialAfter drying over magnesium sulfate
5. concentrationthe chloroform is concentrated to dryness