HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-Formyl-5-chloromethylpyridine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 5-(Hydroxymethyl)pyridine-2-carboxaldehyde | HCID 13518562 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Formyl-5-chloromethylpyridine hydrochloride | HCID 20263964 | — |
Reaction Steps
2-Formyl-5-hydroxymethylpyridine (0.1 mole) in 100 ml. of tetrahydrofuran is treated with 0.11 mole of thionyl chloride, and the mixture is refluxed 3 hours. The product, 2-formyl-5-chloromethylpyridine hydrochloride is collected by filtration from the cooled reaction mixture.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04061759 |
| Source dataset | uspto-grants-1977_12 |
| ORD ID | ord-d53b163ebcd44d2daadb374a07d3ec8a |
| Source note | uspto-grants-1977_12 |