2,4'-Dichloro-3'-sulfamoylacetophenone → HCID 22760429, compound

HRID 461137Notes

Reaction equation

HRID 461137 reaction equation
[Cl:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[C:7]([S:12](=[O:15])(=[O:14])[NH2:13])[CH:6]=1)=[O:4].[N:16]1[CH2:21][CH2:20][CH2:19][NH:18][C:17]=1[SH:22]>>[ClH:1].[Cl:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]2([OH:4])[N:18]3[CH2:19][CH2:20][CH2:21][N:16]=[C:17]3[S:22][CH2:2]2)=[CH:6][C:7]=1[S:12](=[O:15])(=[O:14])[NH2:13]

Participants

3

Reactant 2

HCID 213167492,4'-Dichloro-3'-sulfamoylacetophenoneHCID 178527864HCID 178527864, compound

Product 1

HCID 22760429HCID 22760429, compound

Procedure

5.2 g of 2,4'-dichloro-3'-sulfamoylacetophenone and 2.4 g of ground 3,4,5,6-tetrahydro-2-pyrimidine-thiol were reacted in the manner described in Example 12, the reaction mixture was precipitated with 200 ml of diethyl ether, the solvent was decanted and the oily end product was crystallized under warm ethyl acetate. Colorless crystalline solid body, melting point: 180° C (decomposition).

Workup

  1. customthe reaction mixture was precipitated with 200 ml of diethyl ether
  2. customthe solvent was decanted
  3. customthe oily end product was crystallized under warm ethyl acetate

Sources & evidence

ORD record
ord-2967efc5eca94b089382c2863d9b11cd
Source dataset
uspto-grants-1977_12
Patent number
US04061761

Reaction notes

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