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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 46114Generated: October 29, 2026

4-[2-(4-Methyl-3-nitrophenoxy)ethyl]morpholine → 2-Methyl-5-[2-(morpholin-4-yl)ethoxy]aniline

https://huagongshe.com/reaction/46114

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-[2-(4-Methyl-3-nitrophenoxy)ethyl]morpholineHCID 58929867—
CatalystPalladiumHCID 23938—
SolventMethanolHCID 887—
Product2-Methyl-5-[2-(morpholin-4-yl)ethoxy]anilineHCID 39335039—

Reaction Steps

To the mixture of 4-(2-(4-methyl-3-nitrophenoxy)ethyl)morpholine (532 mg, 2 mmol) in MeOH (50 mL) was added 10% Pd/C (250 mg). The mixture was stirred under an atmosphere of H2 (balloon) overnight. The contents of the reaction mixture were then filtered and concentrated in vacuo to give the title product, which was used without further purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08541592B2
Source datasetuspto-grants-2013_09
ORD IDord-b92268b26e0144e1b41cb66cb5379de2
Source noteuspto-grants-2013_09