Thionyl Chloride → 4-Methyl-3-sulfamoyl-benzoyl chloride

HRID 461153Notes

Reaction equation

HRID 461153 reaction equation
[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[CH:4][C:3]=1[S:11](=[O:14])(=[O:13])[NH2:12].S(Cl)([Cl:17])=O>>[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([Cl:17])=[O:7])=[CH:4][C:3]=1[S:11](=[O:14])(=[O:13])[NH2:12]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 2395854-Methyl-3-sulfamoylbenzoic acid

Product 1

HCID 227605604-Methyl-3-sulfamoyl-benzoyl chloride

Procedure

10 g of 4-methyl-3-sulfamoylbenzoic acid were boiled under reflux for 8 hours in 50 ml of thionyl chloride and the reaction mixture was allowed to stand over night at 0° C. The crystals were collected on a sinter glass frit and washed with petroleum ether and diisopropyl ether. Melting point: 180° C (decomposition).

Workup

  1. waitto stand over night at 0° C
  2. customThe crystals were collected on a sinter glass frit
  3. washwashed with petroleum ether and diisopropyl ether

Sources & evidence

ORD record
ord-846e936f98be4733a0c781478c51f154
Source dataset
uspto-grants-1977_12
Patent number
US04061761

Reaction notes

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