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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 461157Generated: October 25, 2026

2-Chloro-4'-methyl-3'-sulfamoylacetophenone → 3-Hydroxy-3-(4-methyl-3-sulfamoylphenyl)-2,3,6,7-tetrahydro-5H-thiazolo[3,2-a]pyrimidine-hydrochloride

https://huagongshe.com/reaction/461157

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-4'-methyl-3'-sulfamoylacetophenoneHCID 13628783—
ReactantHCID 178527864HCID 178527864—
Product3-Hydroxy-3-(4-methyl-3-sulfamoylphenyl)-2,3,6,7-tetrahydro-5H-thiazolo[3,2-a]pyrimidine-hydrochlorideHCID 22760554—

Reaction Steps

5 g of 2-chloro-4'-methyl-3'-sulfamoylacetophenone and 2.35 g of ground 3,4,5,6-tetrahydro-2-pyrimidine-thiol were reacted as prescribed in Example 12 and worked up as prescribed in Example 67d). Colorless crystals, melting point: 190° C (decomposition).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04061761
Source datasetuspto-grants-1977_12
ORD IDord-adfeee94392d456dabdd82142130dbdc
Source noteuspto-grants-1977_12