N,N'-Dimethylthiourea → 3-Methyl-2-methylimino-4-(3-sulfamoylphenyl)-1,3-thiazolidine-4-ol-hydrochloride

HRID 461165Notes

Reaction equation

HRID 461165 reaction equation
[Cl:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([S:11](=[O:14])(=[O:13])[NH2:12])[CH:6]=1)=[O:4].[CH3:15][NH:16][C:17]([NH:19][CH3:20])=[S:18]>>[ClH:1].[CH3:20][N:19]1[C:3]([C:5]2[CH:10]=[CH:9][CH:8]=[C:7]([S:11](=[O:14])(=[O:13])[NH2:12])[CH:6]=2)([OH:4])[CH2:2][S:18][C:17]1=[N:16][CH3:15]

Participants

3

Reactant 2

HCID 2723631N,N'-DimethylthioureaHCID 220071722-Chloro-3'-sulfamoylacetophenone

Product 1

HCID 227605163-Methyl-2-methylimino-4-(3-sulfamoylphenyl)-1,3-thiazolidine-4-ol-hydrochloride

Procedure

3.5 g of 2-chloro-3'-sulfamoylacetophenone and 1.56 g of ground 1,3-dimethylthiourea were reacted as prescribed in Example 12 and the end product was precipitated with a mixture of 1 part of diethyl ether and 2 parts of ethyl acetate. Colorless crystals, melting point: 184° C.

Workup

  1. customthe end product was precipitated with a mixture of 1 part of diethyl ether and 2 parts of ethyl acetate

Sources & evidence

ORD record
ord-9c36185d4dc548e28b62d6bdf0f8721a
Source dataset
uspto-grants-1977_12
Patent number
US04061761

Reaction notes

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