Bromine → 5-(2-Bromoacetyl)-2-fluorobenzenesulphonamide

HRID 461210Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][C:3]=1[S:11](=[O:14])(=[O:13])[NH2:12].[Br:15]Br>>[Br:15][CH2:9][C:8]([C:5]1[CH:6]=[CH:7][C:2]([F:1])=[C:3]([S:11](=[O:13])(=[O:14])[NH2:12])[CH:4]=1)=[O:10]

Participants

Reactant 2

HCID 24408Bromine

HCID 213316525-Acetyl-2-fluorobenzenesulphonamide

Product 1

HCID 118085905-(2-Bromoacetyl)-2-fluorobenzenesulphonamide

Procedure

12.5 g of 4'-fluoro-3'-sulfamoylacetophenone were reacted as described in Example 12 with 9.2 g of bromine to give the 2-bromo-4'-fluoro-3'-sulfamoylacetophenone, melting point: 125° C.

Sources & evidence

ORD record: ord-18688f9d76d849279ec6f682c35103b1
Source dataset: uspto-grants-1977_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04061761

Reaction notes

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