Fumarate → Monoammonium aspartate

HRID 461233Notes

Reaction equation

HRID 461233 reaction equation
C([O-])(=O)/C=C/C([O-])=O.[NH4+].[NH4+].[NH2:11][C@H:12]([C:17]([O-:19])=[O:18])[CH2:13][C:14]([O-:16])=[O:15].C([O-])(=O)/C=C/C([O-])=O>>[NH3:11].[NH2:11][C@H:12]([C:17]([OH:19])=[O:18])[CH2:13][C:14]([OH:16])=[O:15]

Participants

4

Reactant 3

HCID 5460307FumarateHCID 5460541l-aspartic acid, sodium salt2×HCID 9793847Ammonium fumarate

Product 1

HCID 44153776Monoammonium aspartateYield 90%

Procedure

The enzyme L-aspartase, immobilized by the process of this invention, can be used to convert diammonium fumarate to L-aspartate in 90% yield at pH 7 and 25° C. The immobilized L-aspartase enzyme polymer can be used over and over again to convert fumarate to L-aspartate without significant loss in activity.

Workup

  1. customat pH 7 and 25° C

Sources & evidence

ORD record
ord-cbb0e3f1ad024e5bb26df3d744616abf
Source dataset
uspto-grants-1977_12
Patent number
US04061867

Reaction notes

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