HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 2-Bromo-5-(trifluoromethyl)benzenamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | 3-(Trifluoromethyl)aniline | HCID 7375 | — |
| Reactant | Bromine | HCID 24408 | — |
| Catalyst | Iron | HCID 23925 | — |
| Product | 2-Bromo-5-(trifluoromethyl)benzenamine | HCID 67989 | — |
Reaction Steps
To 161.0 g of m-aminobenzotrifluoride and 10.0 g of iron filings is added, dropwise, with agitation at 35°-40°, 160.0 g of bromine, using a slow stream of nitrogen to sweep out the evolved hydrogen bromide. Subsequently, the mixture is agitated for an additional 2 hours and then distilled in vacuo to give 4-bromo-3-aminobenzotrifluoride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04062846 |
| Source dataset | uspto-grants-1977_12 |
| ORD ID | ord-07101a937af44b0ca9bf8d6e74b4b500 |
| Source note | uspto-grants-1977_12 |