反应详情

温度

100 °C

In a reaction vessel equipped with stirrer, thermometer and drying tube was charged 60 ml. of isoamyl alcohol, 10 g. (0.042 mole) of 4-amino-2-chloro-6,7-dimethoxyquinazoline (prepared as described in U.S. Pat. No. 3,511,836) and 7.3 g. (0.047 mole) ethyl-N-piperazinocarboxylate (Aldrich Chemical Co.). The mixture was heated at 100° C. for 3 hours and allowed to stand overnight at room temperature. The mixture was diluted with 120 ml. of isoamyl alcohol and filtered to obtain 14.3 g. (94%) of the hydrochloride salt of the title compound, which melted sharply at 295° C.

1. customIn a reaction vessel equipped with stirrer
2. customthermometer and drying tube
3. additionwas charged 60 ml
4. additionThe mixture was diluted with 120 ml
5. filtrationof isoamyl alcohol and filtered
6. customto obtain 14.3 g