Aluminium lithium hydride → HCID 21393407, compound

HRID 461341Notes

Reaction equation

HRID 461341 reaction equation
[CH3:1][N:2]1[CH2:21][CH2:20][C:19](=O)[N:5]2[C:6]3[CH:18]=[CH:17][CH:16]=[N:15][C:7]=3[CH2:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[CH:4]2[CH2:3]1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>O1CCOCC1>[CH3:1][N:2]1[CH2:21][CH2:20][CH2:19][N:5]2[C:6]3[CH:18]=[CH:17][CH:16]=[N:15][C:7]=3[CH2:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[CH:4]2[CH2:3]1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 21393406HCID 21393406, compound

Product 1

HCID 21393407HCID 21393407, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

1.46 g (0.05mol) 2-methyl-5-oxo-1,2,3,4,5,15b-hexahydro-11H-benzo[c][1,4]diazepino[1,2-a]pyrido[2,3-f]azepine is added to a suspension of 1.5 g LiAlH4 in 15 ml dry dioxan under nitrogen, and the whole is stirred for 10 minutes at room temperature, after which the reaction mixture is worked up in the way described in example X.2., giving 1.21 g (89%) 2-methyl-1,2,3,4,5,15b-hexahydro-11H-benzo[c][1,4]diazepino[1,2-a]pyrido[2,3-f]azepine as a clear colourless oil.

Sources & evidence

ORD record
ord-23470617d4fb442eb69a319230c307df
Source dataset
uspto-grants-1977_12
Patent number
US04062848

Reaction notes

Loading…