1,2,3,4-Tetrahydroisoquinolin-8-amine → 8-Sulfamoyl-7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline

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Reaction Steps

The above prepared 8-amino tetrahydroisoquinoline compound is converted to the corresponding 8-chlorosulfonyl compound and then to the 8-sulfamoyl compound, 2-acetyl-8-sulfamoyl-7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline, by the procedure of Example 15. The acetyl group is removed by acid hydrolysis by the procedure of Example 15 to give 8-sulfamoyl-7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline.

Provenance & Evidence