HCID 21393826, compound → HCID 21393870, compound

HRID 461504Notes

Reaction equation

HRID 461504 reaction equation
C(N1CCC2C(=C(N)C=CC=2)C1C(F)(F)F)(=O)C.C([N:22]1[CH2:31][CH2:30][C:29]2[C:24](=[C:25]([N+:36]([O-:38])=[O:37])[C:26]([C:32]([F:35])([F:34])[F:33])=[CH:27][CH:28]=2)[CH2:23]1)(=O)C>>[N+:36]([C:25]1[C:26]([C:32]([F:35])([F:33])[F:34])=[CH:27][CH:28]=[C:29]2[C:24]=1[CH2:23][NH:22][CH2:31][CH2:30]2)([O-:38])=[O:37]

Participants

3

Reactant 2

HCID 21393826HCID 21393826, compoundHCID 21393846HCID 21393846, compound

Product 1

HCID 21393870HCID 21393870, compound

Procedure

2-Acetyl-8-amino-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline, prepared as in Example 20, is converted to 2-acetyl-8-nitro-7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline by the procedure of Example 24. Removing the 2-acetyl group by acid hydrolysis according to the procedure of Example 15 gives 8-nitro-7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline.

Workup

  1. customRemoving the 2-acetyl group
  2. customby acid hydrolysis

Sources & evidence

ORD record
ord-f28fd3fc120742d0b7ace610b0a3f765
Source dataset
uspto-grants-1977_12
Patent number
US04062961

Reaction notes

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