反应详情

11.4 gm (0.3 mol) of sodium borohydride were added in small portions at 20°-25° C to 60.7 gm (0.3 mol) of 4'-cyclohexyl-acetophenone (m.p. 66°-67° C) in 300 ml of methanol while stirring vigorously and cooling on ice. The resulting mixture was then stirred for another hour at room temperature, and the reaction product was precipitated with acidified ice water. After suction filtering, washing and drying, 62.6 gm of crystalline material were obtained. A sample, recrystallized from petroleum ether, melted at 81.5°-82.5° C.

1. temperaturecooling on ice
2. stirringThe resulting mixture was then stirred for another hour at room temperature
3. customthe reaction product was precipitated with acidified ice water
4. filtrationAfter suction filtering
5. washwashing
6. customdrying