1,3-Propanediamine → HCID 178433688, compound

HRID 461511Notes

Reaction equation

HRID 461511 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][NH2:5].S([O-])([O-])(=O)=O.CS[C:13]([NH2:25])=[NH+:14][CH2:15][CH2:16][S:17][CH2:18][C:19]1[N:20]=[CH:21][NH:22][C:23]=1[CH3:24].CS[C:28]([NH2:40])=[NH+:29][CH2:30][CH2:31][S:32][CH2:33][C:34]1[N:35]=[CH:36][NH:37][C:38]=1[CH3:39]>O>[CH3:39][C:38]1[NH:37][CH:36]=[N:35][C:34]=1[CH2:33][S:32][CH2:31][CH2:30][N:29]=[C:28]([NH2:40])[NH:1][CH2:2][CH2:3][CH2:4][NH:5][C:13]([NH2:25])=[N:14][CH2:15][CH2:16][S:17][CH2:18][C:19]1[N:20]=[CH:21][NH:22][C:23]=1[CH3:24]

Participants

4

Reactant 2

HCID 4281,3-PropanediamineHCID 20242495S-methyl-N-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]thiouronium sulphate

Product 1

HCID 178433688HCID 178433688, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1,3-Diaminopropane (0.37 g) was added to a solution of S-methyl-N-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]thiouronium sulphate (2.93 g) in water (10 ml) and the mixture was heated under reflux for 2 hours. Following concentration the residue was converted into the picrate with an aqueous solution of sodium picrate. Recrystallisation from ethanol afforded the title compound as the dipicrate (1.1 g) m.p. 114°-6°.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 2 hours
  3. concentrationconcentration the residue
  4. customRecrystallisation from ethanol

Sources & evidence

ORD record
ord-20631f752e1c4d05814980f211dd2a5f
Source dataset
uspto-grants-1977_12
Patent number
US04062967

Reaction notes

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