Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl isothiocyanate | HCID 11167 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-(((5-Methyl-1H-imidazol-4-yl)methyl)thio)ethylamine dihydrochloride | HCID 3015999 | — |
| Solvent | Water | HCID 962 | — |
| Product | Metiamide | HCID 1548992 | — |
Reaction Steps
Potassium carbonate (7.75 g.) was added to a solution of 4-methyl-5-[(2-aminoethyl)thiomethyl]imidazole dihydrochloride (14.6 g.) in water (120 ml.). The solution was stored at room temperature for 15 minutes and methyl isothiocyanate (5.15 g.) was added. After heating under reflux for 30 minutes, the solution was slowly cooled to 5° C. The product was collected and recrystallized from water to give N-methyl-N'-[2-((5-methyl-4-imidazolyl)-methylthio)ethyl]thiourea, m.p. 150°-152° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04063023 |
|---|
| Source dataset | uspto-grants-1977_12 |
|---|
| ORD ID | ord-91b438b35fe445da9a4cf430fa471cbd |
|---|
| Source note | uspto-grants-1977_12 |
|---|
