HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorobenzoyl chloride → 3-[(4-Fluorobenzyl)methylamino]-8-fluoro-1,2,3,4-tetrahydrocarbazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorobenzoyl chloride | HCID 67879 | — |
| Reactant | 4-(Methylamino)cyclohexan-1-ol | HCID 11571804 | — |
| Reactant | 4-(N-methyl-4-fluorobenzamido)-cyclohexanol | HCID 12891878 | — |
| Reactant | 4-(N-methyl-4-fluorobenzamido)-cyclohexanone | HCID 12891880 | — |
| Product | 3-[(4-Fluorobenzyl)methylamino]-8-fluoro-1,2,3,4-tetrahydrocarbazole | HCID 56989532 | — |
Reaction Steps
Following procedures similar to those described in Example 260 there was obtained from 64.6 g. of 4-methylaminocyclohexanol, on reaction with 87.2 g. of 4-fluorobenzoyl chloride, 100.6 g. of 4-(N-methyl-4-fluorobenzamido)-cyclohexanol, m.p. 120°-130° C., 25.1 g. of which were oxidized to give 22.3 g. of 4-(N-methyl-4 -fluorobenzamido)-cyclohexanone, m.p. 132°-136° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04062864 |
| Source dataset | uspto-grants-1977_12 |
| ORD ID | ord-cbc90800ea664cefaf90a5ffd04606cd |
| Source note | uspto-grants-1977_12 |