2-t-Butyl-1,3,4-thiadiazol-5-yl Isocyanate → HCID 21391402, compound

HRID 461579Notes

Reaction equation

HRID 461579 reaction equation
[C:1]([C:5]1[S:9][C:8]([N:10]=[C:11]=[O:12])=[N:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:13][NH:14][CH:15]([CH3:18])[CH:16]=[O:17]>C1C=CC=CC=1>[CH3:13][N:14]([CH:15]([CH3:18])[CH:16]=[O:17])[C:11]([NH:10][C:8]1[S:9][C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])=[N:6][N:7]=1)=[O:12]

Participants

4

Reactant 2

HCID 64524562-t-Butyl-1,3,4-thiadiazol-5-yl IsocyanateHCID 204991472-(Methylamino)propanal

Product 1

HCID 21391402HCID 21391402, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent2×

Procedure

A mixture of 5-t-butyl-1,3,4-thiadiazol-2-yl isocyanate dimer (6 grams), the dimethyl acetal of 2-methylaminopropionaldehyde (5.5 grams) and benzene (20 ml) was charged into a glass reaction flask equipped with a mechanical stirrer and thermometer. The reaction mixture was heated on a steam bath with stirring until all reactants had dissolved. After this time the reaction mixture was stripped of benzene to yield the desired product the dimethyl acetal of 2-[1-methyl-3-(5-t-butyl-1,3,4-thiadiazol-2-yl)ureido]-propionaldehyde as an oil.

Workup

  1. customequipped with a mechanical stirrer
  2. temperatureThe reaction mixture was heated on a steam bath
  3. dissolutionhad dissolved

Sources & evidence

ORD record
ord-d1341a0e6c8c4e7389bc12e68b3c4688
Source dataset
uspto-grants-1977_12
Patent number
US04063924

Reaction notes

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