HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → Orotic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Urea | HCID 1176 | — |
| Reactant | Trichloroacetyl chloride | HCID 6420 | — |
| Reactant | 4,4,4-Trichloro-3-oxobutanoyl chloride | HCID 21391724 | — |
| Product | Orotic Acid | HCID 967 | — |
Reaction Steps
To recap, this invention involves: converting trichloroacetyl chloride with ketone to γ,γ ,γ -trichloroacetoacetyl chloride, adding the reaction mixture to urea dissolved in a polar organic solvent, e.g., acetic acid; evaporating out the resulting 6-trichloromethyluracil; and hydrolyzing the 6-trichloromethyluracil to form orotic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04064126 |
| Source dataset | uspto-grants-1977_12 |
| ORD ID | ord-3be252f833cc47e5a14f6bf37e6b0113 |
| Source note | uspto-grants-1977_12 |