Thionyl Chloride → HCID 21391745, compound

Participants

Reaction Steps

5.5 parts of thionyl chloride is added dropwise to a stirred solution of 9.5 parts of α-hydroxy-α-methyl-m-tolyl 2-thienyl ketone in 40 parts of benzene while keeping the temperature below 20° C. Upon completion, stirring is continued for 1 hour at room temperature and for one additional hour at 30°-35° C. The reaction mixture is evaporated in vacuo. The residue is taken up in toluene and the latter is evaporated again. The residue is distilled, yielding α-chloro-α-methyl-m-tolyl 2-thienyl ketone; b.p. 168°-178° C at 0.7 mm pressure.

Provenance & Evidence