反应详情

A mixture of 23.5 parts of p-ethylphenyl 2-thienyl ketone, 19.5 parts of N-bromosuccinimide, 220 parts of carbon tetrachloride, 1.1 parts of benzoyl peroxide and one drop of toluene is stirred and refluxed for 2 hours. The precipitated succinimide is filtered off and the carbon tetrachloride filtrate is dried and evaporated. The oily residue solidifies on cooling. The solid product is dissolved in 2-propanol and the product is allowed to crystallize. It is filtered off and dried in vacuo, yielding α-bromo-α-methyl-p-tolyl 2-thienyl ketone; m.p. 71.1° C.

1. temperaturerefluxed for 2 hours
2. filtrationThe precipitated succinimide is filtered off
3. dry with materialthe carbon tetrachloride filtrate is dried
4. customevaporated
5. temperatureon cooling
6. dissolutionThe solid product is dissolved in 2-propanol
7. customto crystallize
8. filtrationIt is filtered off
9. customdried in vacuo