反应详情

To a stirred solution of 2.44 parts of 2-aminoethanol in 15 parts of chloroform is added dropwise a solution of 5.6 parts of p-(2-thenoyl)hydratropoyl chloride in 15 parts of chloroform at room temperature (highly exothermic reaction). Upon completion, the whole is stirred and refluxed for 1 hour. The reaction mixture is cooled and washed with a 1N hydrochloric acid solution. The organic layer is separated, washed twice with water, dried, filtered and evaporated. The oily residue solidifies on triturating in petroleumether. The solid product is filtered off and crystallized from boiling ether, yielding N-(2-hydroxyethyl)-p-(2-thenoyl)hydratropamide; m.p. 87.1° C.

1. customhighly exothermic reaction)
2. temperaturerefluxed for 1 hour
3. temperatureThe reaction mixture is cooled
4. washwashed with a 1N hydrochloric acid solution
5. customThe organic layer is separated
6. washwashed twice with water
7. customdried
8. filtrationfiltered
9. customevaporated
10. customon triturating in petroleumether
11. filtrationThe solid product is filtered off
12. customcrystallized