反应详情

To 5.0 g of refined 1-isopropyl-4-(3-hydroxyphenyl)-7-methyl-2(1H)-quinazolinone in a vessel, is added 100 ml. of acetic anhydride and 0.5 ml of concentrated sulfuric acid. The resulting mixture is allowed to stand for 16 hours. The reaction mixture is then poured over salted ice in a vessel. After the ice has melted, the resulting liquid is extracted twice with 300 ml portions of benzene: n-butanol (4:1) and the combined extracts washed with distilled water until free of acid, and then evaporated to obtain a residue. The residue is crystallized from methanol to obtain the title product, m.p. 148°-150°.

1. additionThe reaction mixture is then poured over salted ice in a vessel
2. extractionthe resulting liquid is extracted twice with 300 ml portions of benzene: n-butanol (4:1)
3. washthe combined extracts washed with distilled water until free of acid
4. customevaporated
5. customto obtain a residue
6. customThe residue is crystallized from methanol