Ammonia → 2-Azaalanyl-DL-lactamide

HRID 461783Notes

Reaction equation

HRID 461783 reaction equation
C([O:3][C:4](=O)[C:5]([C:8](=[O:12])[N:9]([CH3:11])[NH2:10])([CH3:7])[OH:6])C.[NH3:14]>>[NH2:10][N:9]([C:8]([C:5]([CH3:7])([OH:6])[C:4]([NH2:14])=[O:3])=[O:12])[CH3:11]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 1317109802-Azaalanyl-dl-lactic acid ethyl ester

Product 1

HCID 1317109792-Azaalanyl-DL-lactamide

Procedure

2-Azaalanyl-dl-lactic acid ethyl ester (0.02 mole) is treated with liquid ammonia (50 ml) at room temperature for 16 hours. The mixture is evaporated to dryness. Chromatography on silica gel (80 gm) and elution with 15% methanol in chloroform gives 2-azaalanyl-dl-lactamide.

Workup

  1. customThe mixture is evaporated to dryness
  2. washChromatography on silica gel (80 gm) and elution with 15% methanol in chloroform

Sources & evidence

ORD record
ord-8cb7073c1ede4b9fb6c85d0518d097a4
Source dataset
uspto-grants-1977_12
Patent number
US04064236

Reaction notes

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