Water → HCID 53991412, compound

HRID 461798Notes

Reaction equation

HRID 461798 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:9][CH:10]([OH:24])[CH2:11][N:12]([CH2:19][C:20]([O:22][CH3:23])=[O:21])[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:4][CH:3]=1.[C:25](OC(=O)C)(=[O:27])[CH3:26].O>N1C=CC=CC=1>[C:25]([O:24][CH:10]([CH2:11][N:12]([CH2:19][C:20]([O:22][CH3:23])=[O:21])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:9][S:8][C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1)(=[O:27])[CH3:26]

Participants

5

Reactant 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 12801101HCID 12801101, compound

Product 1

HCID 53991412HCID 53991412, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

After 200 mg (0.00054 moles) of 1-(p-chlorophenylthio)-3-(N-carbomethoxymethyl-N-phenylamino)-2-propanol and 1 g of acetic anhydride were dissolved in 3 ml of pyridine and left to stand at room temperature for 20 hr, the reaction mixture mixture was poured into iced water and extracted with ether. The ether layer was washed with 10% hydrochloric acid and water and dried. Evaporation or ether under reduced pressure gave 190 mg (86.5%) of an oily substance.

Workup

  1. waitleft
  2. extractionextracted with ether
  3. washThe ether layer was washed with 10% hydrochloric acid and water
  4. customdried
  5. customEvaporation or ether under reduced pressure
  6. customgave 190 mg (86.5%) of an oily substance

Sources & evidence

ORD record
ord-169277c1b435428aa2a080e056322b31
Source dataset
uspto-grants-1977_12
Patent number
US04064252

Reaction notes

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