反应详情

To a solution of 5-(4-chlorophenyl)-5-[3-(2,5-dimethylpyrrolidin-1-yl)-3-oxopropyl]-6-methoxy-5H-imidazo[2,1-a]isoindole (190 mg) in CH2Cl2 (2 mL) was added BBr3 (1.7 ml) slowly at 0° C. After 90 min the mixture was quenched with saturated aqueous NaHCO3. The layers were separated and the aqueous layer was extracted with CH2Cl2 (3×). The combined organic layers were dried (Na2SO4), filtered, and concentrated to an off-white solid (179 mg) which was sufficiently pure for use in the next step.

1. customAfter 90 min the mixture was quenched with saturated aqueous NaHCO3
2. customThe layers were separated
3. extractionthe aqueous layer was extracted with CH2Cl2 (3×)
4. dry with materialThe combined organic layers were dried (Na2SO4)
5. filtrationfiltered
6. concentrationconcentrated to an off-white solid (179 mg) which