反应详情

温度

0 °C

3-Isothiocyanatopyridine (6.8 g.) is added to a solution of (S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline (8.15 g.) in ethanol (150 cc.). After 3 hours at a temperature of about 20° C., the solution is cooled to 0° C. The white crystals which have appeared are filtered off and are then recrystallised from propanol (200 cc.). After filtration, the crystals are washed with propanol (2 × 10 cc.) and then dried at 60° C. under reduced pressure (1 mm. Hg). (S)-3-Hydroxymethyl-N-(pyrid-3-yl)-1,2,3,4-tetrahydroisoquinoline-2-carbothioamide (12.1 g.) melting at 192° C is thus obtained.

1. filtrationThe white crystals which have appeared are filtered off
2. customare then recrystallised from propanol (200 cc.)
3. filtrationAfter filtration
4. washthe crystals are washed with propanol (2 × 10 cc.)
5. customdried at 60° C. under reduced pressure (1 mm. Hg)