[(3S)-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol → (S)-3-Hydroxymethyl-N-(isoquinol-5-yl)-1,2,3,4-tetrahydroisoquinoline-2-carbothioamide

참여 물질

반응 단계

5-Isothiocyanatoisoquinoline (0.93 g.) is added to a solution of (S)-3-hydroxymethyl-1,2,3,4-tetrahydro isoquinoline (0.82 g.) in ethanol (10 cc.). After 15 hours at a temperature of about 20° C., the crystals formed are filtered off, washed with ethanol and then dried at 60° C. under reduced pressure (0.1 mm. Hg). (S)-3-Hydroxymethyl-N-(isoquinol-5-yl)-1,2,3,4-tetrahydroisoquinoline-2-carbothioamide (1.3 g. ), melting at 190° C., is thus obtained.

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