反应详情

(S)-1,5,10,10a-Tetrahydrothiazolo[3,4-b]isoquinoline-3-thione (38 g.) is dissolved in methyl iodide (500 cc.). After 15 hours at a temperature of about 20° C., the crystals which have appeared are filtered off, washed with diethylether (2 × 50 cc.) and then dried at 20° C. under reduced pressure (1 mm. Hg) to give (S)-3-methylthio-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinolinium iodide (61.5 g.) melting at 140°-150° C. with decomposition.

1. filtrationthe crystals which have appeared are filtered off
2. washwashed with diethylether (2 × 50 cc.)
3. customdried at 20° C. under reduced pressure (1 mm. Hg)