反应详情

(S)-7-Nitro-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinoline-3-thione (16 g.) is dissolved in methyl iodide (800 cc.). After 15 hours at a temperature of about 20° C., the crystals which have appeared are filtered off, washed with diethyl ether (2 × 30 cc.) and then dried at 20° C., under reduced pressure (1 mm.Hg). (S)-3-Methylthio-7-nitro-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinolinium iodide (23.3 g.) is thus obtained.

1. filtrationthe crystals which have appeared are filtered off
2. washwashed with diethyl ether (2 × 30 cc.)
3. customdried at 20° C., under reduced pressure (1 mm.Hg)