Ethanol → HCID 178439276, compound

HRID 461830Notes

Reaction equation

HRID 461830 reaction equation
[CH2:1]([C:4]1[C:13]2[O:12][C:11]([C:14]3[NH:18][N:17]=[N:16][N:15]=3)=[CH:10][CH2:9][C:8]=2[C:7]([O:19][CH2:20][CH2:21][CH:22]([CH3:24])[CH3:23])=[CH:6][CH:5]=1)[CH:2]=[CH2:3].C([OH:27])C>[Pd]>[CH3:23][CH:22]([CH3:24])[CH2:21][CH2:20][O:19][C:7]1[C:8]2[C:9](=[O:27])[CH:10]=[C:11]([C:14]3[NH:15][N:16]=[N:17][N:18]=3)[O:12][C:13]=2[C:4]([CH2:1][CH2:2][CH3:3])=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 702EthanolHCID 178439274HCID 178439274, compound

Product 1

HCID 178439276HCID 178439276, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A solution of 1.0 parts of 5-[8-allyl-5-(3-methyl-n-butoxy)-4H-1-benzopyran-2-yl]tetrazole in 19 parts of ethanol was hydrogenated overnight at room temperature and pressure using 0.02 parts of 5% palladium on charcoal as catalyst. The reaction mixture was filtered and the solvent removed by evaporation. Cystallisation of the residue from ethanol gave 0.52 parts of 5-[5-(3-methyl-n-butoxy)-8-n-propyl-4-oxo-4H-1-benzopyran-2-yl]tetrazole, m.p. 202°-204° C.

Workup

  1. filtrationThe reaction mixture was filtered
  2. customthe solvent removed by evaporation

Sources & evidence

ORD record
ord-85824b78b371466895c70bf384436e5e
Source dataset
uspto-grants-1977_12
Patent number
US04064256

Reaction notes

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