HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 3-Tert-butyl-4-hydroxy-5-iodobenzylidenemalononitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Malononitrile | HCID 8010 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 3-Tert-butyl-4-hydroxy-5-iodobenzaldehyde | HCID 18677384 | — |
| Solvent | Benzene | HCID 241 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Tert-butyl-4-hydroxy-5-iodobenzylidenemalononitrile | HCID 54462800 | 84.3% |
Reaction Steps
3-tert-butyl-4-hydroxy-5-iodobenzaldehyde (24.8 gm), malononitrile (6.2 gm), piperidine (1.0 ml), acetic acid (3.3 ml) and benzene (300 ml) were refluxed under a Dean and Stark water separator for 2 hours. On cooling a crystalline precipitate formed and was filtered off. Recrystallisation from ethylene dichloride gave pale yellow needles of 3-tert-butyl-4-hydroxy-5-iodobenzylidenemalononitrile (24.2 gm) m.p. 188°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04064266 |
| Source dataset | uspto-grants-1977_12 |
| ORD ID | ord-6264988a23e04841afde046a04b55b72 |
| Source note | uspto-grants-1977_12 |