HuagongsheHuagongshe Chemistry Print Report · For research reference only
N'-(4-Chloroacetylaminophenyl)-N,N-dimethylacetamidine hydrochloride → Chloroacetyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N'-(4-Chloroacetylaminophenyl)-N,N-dimethylacetamidine hydrochloride | HCID 21392874 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Chloroacetyl chloride | HCID 6577 | — |
| Product | N'-(4-Aminophenyl)-N,N-dimethylacetamidine | HCID 169706 | — |
Reaction Steps
N'-(4-Chloroacetylaminophenyl)-N,N-dimethylacetamidine hydrochloride, used as the starting material in Step B of this example, is obtained by the acylation of 74.5 g of N'-(4-aminophenyl)-N,N-dimethylacetamidine with 54.7 g of chloroacetyl chloride in tetrahydrofuran to afford 104.7 g of the product. Upon recrystallization from alcohol the N'-(4-chloroacetylaminophenyl)-N,N-dimethylacetamidine hydrochloride has a melting point of 246°-247° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04064270 |
| Source dataset | uspto-grants-1977_12 |
| ORD ID | ord-35812118804a4ca5b353580762177c9f |
| Source note | uspto-grants-1977_12 |