反应详情

The preceding Intermediate 1 (compound 6, mixture of α,β-anomer in about 1:2 ratio, 105 g, 156 mmol) was slurried in ethanol (1 L) and heated to reflux with stirring. The reaction mixture was held at reflux for 1 h to ensure that all of solution had homogenized; it was then cooled evenly at 15 t/h to ambient temperature and stirred overnight at this temperature. The resulting solid was isolated by filtration and dried in vacuo to yield the title compound (53 g, 79 mmol, 51%) as a white solid.

1. temperatureheated
2. temperatureto reflux
3. temperatureat reflux for 1 h
4. stirringhad homogenized
5. stirringstirred overnight at this temperature
6. customThe resulting solid was isolated by filtration
7. customdried in vacuo