反应详情

In a further example, p-nitrobenzyl 7-amino-3-methylenecepham-4-carboxylate hydrochloride is dissolved in methanol and ozone is bubbled through the solution at a temperature of about -78° C. Excess ozone is purged from the mixture with nitrogen and the ozonide is decomposed by bubbling sulfur dioxide through the mixture. The reaction mixture is evaporated to dryness and the residue, p-nitrobenzyl 7-amino-3-hydroxy-3-cephem-4-carboxylate is obtained as the hydrochloride salt.

1. customozone is bubbled through the solution at a temperature of about -78° C
2. customExcess ozone is purged from the mixture with nitrogen
3. customby bubbling sulfur dioxide through the mixture
4. customThe reaction mixture is evaporated to dryness