4-Benzylpiperidine → HCID 515313, compound

HRID 461961Notes

Reaction equation

Cl[CH2:2][CH2:3][CH2:4][CH2:5][C:6]([C:8]1[CH:20]=[CH:19][C:18]2[C:17]3[C:12](=[CH:13][C:14]([C:21](=[O:27])[CH2:22][CH2:23][CH2:24][CH2:25]Cl)=[CH:15][CH:16]=3)[CH2:11][C:10]=2[CH:9]=1)=[O:7].[CH2:28]([CH:35]1[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]1)[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>>[CH2:28]([CH:35]1[CH2:40][CH2:39][N:38]([CH2:2][CH2:3][CH2:4][CH2:5][C:6]([C:8]2[CH:20]=[CH:19][C:18]3[C:17]4[C:12](=[CH:13][C:14]([C:21](=[O:27])[CH2:22][CH2:23][CH2:24][CH2:25][N:38]5[CH2:39][CH2:40][CH:35]([CH2:28][C:29]6[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=6)[CH2:36][CH2:37]5)=[CH:15][CH:16]=4)[CH2:11][C:10]=3[CH:9]=2)=[O:7])[CH2:37][CH2:36]1)[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1

Participants

Reactant 2

HCID 317384-Benzylpiperidine

HCID 21392932HCID 21392932, compound

Product 1

HCID 515313HCID 515313, compound

Procedure

Following the procedure of Example 7, 20.2g (0.05 mole) of 2,7-bis(5-chlorovaleryl)fluorene, prepared in Example 2, and 70.0g (0.4 mole) of 4-benzylpiperidine were reacted to give the desired product which was recrystallized three times from chloroform-acetone. M.P. 147°-149° C, λmaxEtOH 329, E1cm1% 577.

Workup

customwere reacted

Sources & evidence

ORD record: ord-925aaf5eb14c425c95b46032fc395c44
Source dataset: uspto-grants-1977_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04064347

Reaction notes

Loading…