2,2,2-Trichloroethanimidamide → HCID 178512121, compound

Participants

Reaction Steps

A solution of gramine methiodide (31.6 g., 0.1 mole) in 250 ml. of ethanol is treated dropwise over a period of 30 minutes with a solution of trichloroacetamidine (16.1 g., 0.1 mole) in 50 ml. of ethanol. The solution is refluxed for 15 minutes, cooled and the solvent removed in vacuo to give a crystalline residue. The residue is partitioned between 150 ml. portions of chloroform and water and the water layer back-extracted with chloroform. The combined chloroform extracts are washed with water, dried over magnesium sulfate, filtered and concentrated in vacuo affording N-(3-indolylmethyl)-trichloroacetamidine m.p. 135.5 to 138.5 after recrystallization from benzene/hexane.

Provenance & Evidence