反应详情

温度

100 °C

A suspension of 1-ethyl-4-hydroxy carbostyril (1.09 g; 0.00575 mole) in glacial acetic acid (5 ml) was swirled during the rapid addition of concentrated nitric acid (1.25 ml; d 1.42) and the dark liquid heated for 5 minutes at 100° C. The yellow solid which separated on cooling was filtered off and washed well with ethanol m.p. 154°-5° C (decomp). (Found; C, 56.54; H, 4.52; N, 11.56; C11H10N2O4 requires; C, 56.41; H, 4.30, N, 11.96%).

1. customThe yellow solid which separated
2. temperatureon cooling
3. filtrationwas filtered off
4. washwashed well with ethanol m.p. 154°-5° C (decomp)