HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 7-Chloro-4-hydroxy-1-methyl-2(1H)-quinolinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 4-Chloro-2-(methylamino)benzoic acid | HCID 12535368 | — |
| Solvent | Acetic Anhydride | HCID 7918 | — |
| Product | 7-Chloro-4-hydroxy-1-methyl-2(1H)-quinolinone | HCID 54696298 | — |
Reaction Steps
Refluxing a solution of 4-chloro-N-methyl anthranilic acid (13.6g; 0.073 mole) in acetic acid (37 ml) and acetic anhydride (37 ml) for 6 hours and work up as described in Example 35(a) gave the title compound; m.p. (AcOH, EtOH) 308°-9°. (Found; C, 56.97; H, 4.03; N, 6.89 Cl, 16.82; C10H8NClO2 requires; C, 57.29; H, 3.85; N, 6.68; Cl, 16.91%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04065457 |
| Source dataset | uspto-grants-1977_12 |
| ORD ID | ord-6f3e18f8328147f99411a5c88a8f37ac |
| Source note | uspto-grants-1977_12 |