HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitric Acid → 4-hydroxy-3-nitro-1-phenylquinolin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | 4-Hydroxy-1-phenyl-1,2-dihydroquinolin-2-one | HCID 54676161 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 4-hydroxy-3-nitro-1-phenylquinolin-2(1H)-one | HCID 54683888 | — |
Reaction Steps
A solution of 4-hydroxy-1-phenyl carbostyril (2.20g.; 0.0093 mole) in glacial acetic acid (10 ml.) was treated rapidly with concentrated nitric acid (2.5 ml. d 1.42) and the mixture heated on a steam bath for 21/2 mins. The red solution deposited a dark yellow solid on cooling which, after dilution with ethanol, was filtered off and washed well with ethanol, m.p. (AcOH -- EtOH) 167° - 169° C. (Found; C, 64.13; H, 3.70; N, 9.85; C15H10N2O4 requires; C, 63.83; H, 3.57; N, 9.92%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04065457 |
| Source dataset | uspto-grants-1977_12 |
| ORD ID | ord-a69f5488a0de4c33a7336ae511963b3d |
| Source note | uspto-grants-1977_12 |