HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 2-Chloro-10-[4-(1-pyrrolidinyl)-2-butynyl]phenothiazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 2-Chloro-10-propargylphenothiazine | HCID 14959696 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-Chloro-10-[4-(1-pyrrolidinyl)-2-butynyl]phenothiazine | HCID 21390490 | — |
Reaction Steps
Following the procedure given in Example 1B, 2-chloro-10-propargylphenothiazine (21.7 g.; 0.08 mole) was caused to react with 3.8 g of paraformaldehyde and 7.1 g. (0.1 mole) of pyrrolidine in the presence of a trace of cuprous chloride in dioxane. Recrystallized from ether-hexane, the pure 2-chloro-10-[4-(1-pyrrolidinyl)-2-butynyl]-phenothiazine thus obtained melted at 48.0°-50.0° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04065471 |
| Source dataset | uspto-grants-1977_12 |
| ORD ID | ord-f4063b9546c647f9ad2e9670c7ee508a |
| Source note | uspto-grants-1977_12 |