Ethyl Acetate → Methyl 2-(2-Chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl)phenyl)-2-(7-methylbenzo[e][1,2,4]triazin-3-yl)acetate

Participants

Reaction Steps

3-(1-(2-Chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl)phenyl)-2-methoxy-2-oxoethyl)-7-methylbenzo[e][1,2,4]triazine 1-oxide (compound 61, 310 mg, 0.36 mmol) was treated with Zn (500 mg, 7.6 mmol) and ammonium chloride (500 mg, 9.34 mmol) in aqueous dioxane at room temperature for 1 day. The reaction mixture was diluted and work-up with EtOAc. After evaporating the volatile solvent under reduced pressure, the residue was purified with silica gel column (Hx/EtOAc=⅓) to afford title compound (228 mg, 75% yield) as white solid.

Provenance & Evidence