反应详情

4.7 g of N-(6-chloromethyl-3,4-methylenedioxyphenethyl) acetamide was dissolved in 10 ml of DMSO and 1.32 g (0.028 mole) of sodium cyanide added to the stirred solution. Within a few minutes, the temperature rose from 25° to 32° C. After 1.5 hrs at ambient temperature the mixture was poured into ice and water. The suspension was extracted with three 50-ml portions of benzene. The benzene layers were washed with saturated brine six times, then with water, the solution dried, and the solvent distilled in the rotary evaporator leaving the above-named product as a crystalline solid, m.p. 153.3-155.5.

1. waitWithin a few minutes
2. customrose from 25° to 32° C
3. extractionThe suspension was extracted with three 50-ml portions of benzene
4. washThe benzene layers were washed with saturated brine six times
5. dry with materialwith water, the solution dried
6. distillationthe solvent distilled in the rotary evaporator