Benzene → HCID 54240701, compound

HRID 462110Notes

Reaction equation

HRID 462110 reaction equation
[CH2:1]1[O:14][C:13]2[C:3](=[CH:4][C:5]3[CH2:11][CH2:10][NH:9][CH2:8][CH2:7][C:6]=3[CH:12]=2)[O:2]1.C1C=CC=CC=1.[OH-].[Na+].[Cl:23][CH2:24][C:25](Cl)=[O:26]>O>[Cl:23][CH2:24][C:25]([N:9]1[CH2:10][CH2:11][C:5]2[CH:4]=[C:3]3[O:2][CH2:1][O:14][C:13]3=[CH:12][C:6]=2[CH2:7][CH2:8]1)=[O:26]

Participants

6

Reactant 4

HCID 241BenzeneHCID 6577Chloroacetyl chloride2×HCID 14798Sodium Hydroxide2×HCID 21824590HCID 21824590, compound

Product 1

HCID 54240701HCID 54240701, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

One-tenth mole, 22.7 g, of 2,3,4,5-tetrahydro-7,8-methylenedioxy-1H-3-benzazepine was dissolved in 200 ml of water and 200 ml of benzene added. Forty ml of a 10% solution of sodium hydroxide was added to the vigorously stirred emulsion and 17 g (0.15 mole) of chloroacetyl chloride was added dropwise. As the pH approached 5, another 10-ml portion of 10% sodium hydroxide solution was added until a total of 100 ml has been added. After all the chloroacetyl chloride had been added, the mixture, which has an acid reaction, was stirred for another 10 minutes then allowed to stand overnight at room temperature.

Workup

  1. additionwas added dropwise
  2. additionhas been added
  3. customan acid reaction
  4. waitto stand overnight at room temperature

Sources & evidence

ORD record
ord-37bd1aac4d654aab97facab07eb497f8
Source dataset
uspto-grants-1977_12
Patent number
US04065473

Reaction notes

Loading…