Acetic Anhydride → 2-(2-Acetamido-5-thiadiazolyl)-1-methyl-5-nitroimidazole

Participants

Reaction Steps

The above compound is prepared by heating under reflux for 30 minutes a mixture of 14 gm. of 2-(2-amino-5-thiadiazolyl)-1-methyl-5-nitroimidazole in 280 ml. of acetic anhydride. The mixture is evaporated to dryness, and the solid residue is washed thoroughly with ether giving 16.4 gm. of a yellow solid having a melting point of 235° C. (decomposition).

Provenance & Evidence