反应详情

A mixture consisting of 4.9 gm., 0.02 mole, of 2-(2-chloro- 5-thiadiazoly)-1-methyl-5-nitroimidazole, 3.0 gm., 0.05 mole, of ethanolamine, and 50 ml. of p-dioxane is stirred at room temperature for twenty-four hours. The precipitate is collected, washed with aqueous sodium bicarbonate solution, dried and recrystallized from methanol to give the pure compound melting at 208°-209° C. Working up the mother liquors gives additional material, the total yield being 3.4 gm.

1. customThe precipitate is collected
2. washwashed with aqueous sodium bicarbonate solution
3. customdried
4. customrecrystallized from methanol