1-(Thiazol-2-yl)piperazine → 2-{2-[4-(2-Thiazolyl)-1-piperazinyl]-5-thiadiazolyl]-1-methyl-5-nitroimidazole

Participants

Role	Name	HCID	Charge
Reactant	1-(Thiazol-2-yl)piperazine	HCID 911806	—
Reactant	1-[3-(Dimethylamino)propyl]piperazine	HCID 2736234	—
Reactant	2-{2-[4-(3-Dimethylaminopropyl)-1-piperazinyl]-5-thiadiazolyl}-1-methyl-5-nitroimidazole	HCID 21390803	—
Product	2-{2-[4-(2-Thiazolyl)-1-piperazinyl]-5-thiadiazolyl]-1-methyl-5-nitroimidazole	HCID 21390853	—

Reaction Steps

The preparation of the subject compound is carried out essentially as described for the 2-[4-(3-dimethylaminopropyl)-1-piperazinyl] derivative (Example 35), an equivalent of 1-(2-thiazolyl)piperazine replacing the 1-(3-dimethylaminopropyl)piperazine. After recrystallization from 2-methoxyethanol, the pure compound melts at 297°-300° C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04065567
Source dataset	uspto-grants-1977_12
ORD ID	ord-10dfc038fa9d47f89d1562cb38168a32
Source note	uspto-grants-1977_12