反应详情

A mixture of 5.0 g. of 2-(2-chloro-5-thiadiazolyl)-1-methyl-5-nitroimidazole, 6.0 g. of cyclohexylamine and 125 ml. of dioxane is stirred at reflux until thin-layer chromatographic analysis indicates that the chloro intermediate is completely utilized. The dioxane is removed under reduced pressure and the residue triturated with aqueous sodium bicarbonate solution. Recrystallization from a mixture of ethylacetate and acetone yields the pure compound melting at 215°-217° C.

1. additionA mixture of 5.0 g
2. temperatureat reflux until thin-layer chromatographic analysis
3. customThe dioxane is removed under reduced pressure
4. customthe residue triturated with aqueous sodium bicarbonate solution
5. customRecrystallization
6. additionfrom a mixture of ethylacetate and acetone